ea0032p537 | Endocrine tumours and neoplasia | ECE2013
Martins Clarissa
, Camargo Renata
, Saggioro Fabiano
, Neder Luciano
, Machado Helio
, Moreira Ayrton
, Castro Margaret
Introduction: Abnormalities in cell cycle pathways, such as CDKN1B (p27) underexpression, have been identified in the pathogenesis of pituitary adenomas, but their underlying mechanisms have not been elucidated. Ribosomal proteins have been recently related to pituitary tumorigenesis. In gastric cancer, RPS13 down-regulates p27 and promotes cell cycle progression; these mechanisms have not yet been explored in pituitary adenomas.Objective: To evaluate th...